A haptic alert system for use in a vehicle includes a sensor system operable to identify a condition associated with the vehicle; a control system in communication with the sensor system; and a remote haptic device in communication with the sensor system. The invention also provides methods for detecting growth factor receptor phosphorylation in hair follicles and other tissues obtained by non-invasive means. 17 communication from the transmitter, V. Moreover, a step for forming a silicon dioxide film 205 on the re-crystallization film is included. In an embodiment, a writing instrument sheath includes a contiguous wall and a polymer layer that provides a comfortable and controllable writing experience.