The present invention describes methods for introducing nucleic acids into a target cell using a transition metal enhancer. The adjusting device includes an adjusting gear system which is embodied as a triple-shaft gear mechanism and is provided with a crankshaft-fixed input part, a camshaft-fixed output part, and an adjusting shaft that is connected in a torsion-proof manner to an electric adjusting motor shaft of an electric adjusting motor. In one design, samples containing a desired signal centered at DC or a frequency higher than DC may be partitioned into blocks of K samples. If monomers exhibiting solid state reactivity are utilized, the particles thus formed can be polymerized at any time after formation.