The invention concerns novel substituted 6-benzyl-4-oxopyrimidines and pharmaceutically acceptable salts thereof. According to the method, program data including a commercial is recorded. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In response to configuration information, the interconnection network is operative in real-time to configure and reconfigure the plurality of heterogeneous computational elements for a plurality of different functional modes, including linear algorithmic operations, non-linear algorithmic operations, finite state machine operations, memory operations, and bit-level manipulations. The black phosphorus or black phosphorus-carbon composite is prepared by using high energy ball-milling, which is easy and efficient way in transforming amorphous red phosphorus into orthorhombic black phosphorus at ambient temperature and pressure.