A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity. In one embodiment, a buckle assembly is configured to detachably engage latch plates. Focus can thereby be obtained over the entire image plane, so that a reduction in contrast is prevented, even if the optical axis is inclined to make an optical system smaller. This is enabled by the fact that a full swing CMOS delay cell can be made to have good delay matching over PVT, whereas the input stage to a differential amplifier may, depending on architecture, have poor delay matching because of impedance mismatches within the amplifier. The present invention also provides a means for increasing biaxial strain with strain inducing isolation regions.