This document discusses, among other things, method and apparatus for a non-nutritive suck entrainment pulse generator. The illumination device is configured to be in proximity with a fabrication system and illuminates a portion of the structure. Instead of having to transmit the entire application, some embodiments transmit only a small portion that is reflective of what has been changed between the old version of the application and the new version of the application. In addition, search results from multiple search engines are combined into an organization scheme that best reflects the user’s current task. The method can also be applied to determine the trajectory of an in-fill well to be drilled. The compounds provided by the invention act specifically on metabotropic glutamate receptors and are used as medicaments.