The invention relates to a method for fabricating a locally passivated germanium-on-insulator substrate wherein, in order to achieve good electron mobility, nitridized regions are provided at localized positions. An instrument embodying the invention includes a plurality of detection devices that are arranged in a predetermined pattern on a tissue contacting face of the instrument. The one or more canards are adjustable between two or more canard configurations. There is only one type of metric possible for the largest granular policer, so the only way to implement multiple system-wide metrics is to repeat the hierarchy multiple times over, which adds to the delay of the packet and the complexity of the router. The invention provides a peptide with a potent NO-scavenging ability which can be used in capturingquantifying NO and can be used as a diagnostic agent, prophylactic agent or therapeutic agent for diseases in which NO is involved, as a research reagent, as a reagent for measuring NO concentrations in the environment, and as a treating agent for removing NO in the environment. Further, the use of this very high concentration of osmolality-increasing compound in the wetting fluid has proven remarkably efficient.