A system controls use of a mobile device in a vehicle where the mobile device includes, a hands-on user interface and a wireless communication interface. Methods for detecting variations and for diagnosing and treating tumors are provided. For HARQ-ACK timing, in cases where a reference UL-DL configuration applied to the second cell is #0, the DAI field is not used in a process of transmitting the HARQ-ACK information. The multiplicative factor iterations may involve predetermined algorithms, such as squaring and powers of two iterations. The multiple bitrate algorithm is then allowed to request the different bitrate version of the media program based on the available bandwidth reading. When fuel level is too low or the energy stored in a batter is insufficient, the system can be configured to inhibit vehicle operation.