A method for forming a non-linear thickness-profile in a first layer of a first material is disclosed. The system has a water-cooled housing supporting a termination block, which is operative to shield a protective layer of a delivery fiber from back-reflected beams of light. The light detection unit illuminates the correction image on the image carrying member and detects light reflected thereby. The walls of the hole impose forces onto the shank along this bearing surface which tend to deform shank into alignment with the hole by primarily elastic deformation so that the resulting frictional forces between the shank and the wall resist dislodgment from the hole. The most active transcription inhibitor compound of this series 5b ethoxyphenyl)butane tetrakishydrochloride salt) has an IC50 of 0. The topological graph includes several topological items including a set of items for each net that represent the net’s routable elements.