A method is delineated for detecting and locating coronary artery and heart disease comprising the steps of obtaining electrocardiograph signals from a patient, modifying the EKG signals, and establishing a base value for use in evaluating modified EKG signals. After the stabilizing processing, the control unit sets the values of the excitation currents back to values for the measurement in order to measure dimensions of the sample, the excitation currents respectively supplied to the first and second condenser lenses. In the display device, letting d2 and d3 denote, respectively, a film thickness of the silicon nitride film and a film thickness of the second silicon oxide film, these films are stacked to satisfy the relationship d2<d3, and the contact hole is formed to have a tapered shape free of constrictions. The DNA sequences in the concatamer may encode the compliment C3 fragment C3d or an analogue thereof.