A telephony application architecture which allows creating programs as a set of nested routines running independently and concurrently on three different control layers. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis. The shock absorber is mounted in the bicycle frame and comprises a first connecting member connected pivotally to the upper linkage device, and a second connecting member connected pivotally and coaxially to the lower linkage device and the front frame. Following the assembly of the stack an induction welding step occurs at predetermined locations to secure the pinless alignment. The system also provides an opening configured to permit the frame to be postured about a patient such that an isocenter corresponds to a region of interest of the patient, and includes an illumination source attached to the frame and configured to direct illumination towards the isocenter.