A method for fabrication of substrate having a nano-scale surface roughness is presented. Processes for making such material, as well as products related thereto, are also disclosed. The example method may arrange the at least one N-channel transistor between the first and second sub array blocks. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample. This modification of centrifugal weight position causes a corresponding change to engagement characteristics of the clutch assembly allowing clutch actuation to be tailored to operating conditions.