Disclosed is a NRD waveguide mixer adopting a ring hybrid coupler applicable to a small-sized and high functional millimeter wave receivingtransmitting device. Methods of modulating angiogenesis by administering an anti-angiogenic ANG-7 nucleic acid are also provided. Wooden members are placed into each of the elongated slots to form an assembled combination of the foam form and wood members. Flow control filtering mechanisms and a variable reliability margin may be used to adapt dynamically to the current data traffic conditions. Such an illumination device may allow lighting of a room, for instance via the ceiling with uplight, and lighting of a specific area in the room with downlight.