The invention is directed to compounds of Formula I:wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. The flange preferably floats at or near the top of the water, in a partially-submerged position, with a generally concave front surface facing the hook or fly. The molar ratio as oxides of the main component elements is given by z O9 provided that 0x, y0.