The present invention relates to methods for identifying agents that modulate the effect of cytokine class I receptor binding compounds, by inhibiting the interaction between the cytokine class I receptor and nuclear factors. 5 nm or more is formed at a boundary between an Si substrate and a high dielectric insulation film, and the temperature for forming the SiO2 film is made higher than the source-drain activating heat treatment temperature in the subsequent steps. For each level of the configuration, the predictive model computes a performance metric based on a portion of the workload satisfied at the level and the cache characteristics of the level. The second panel section also becomes separated from the first film layer when the second film layer is separated from the first film layer to provide an indication of an initial opening of the closure. The second request signal requests permission for the second transceiver module to transmit or receive.