Provided are agents and methods for use in depleting serum amyloid P component from a patient in need thereof. The device can determine the type of dock and change the pin outs for a connector to interface with that dock. At least one internal passageway in the rotor and elements for: pre-heating some or all the incoming fluid in the chamber; priming the chamber initially; cooling certain temperature sensitive components; injecting fluid into a partially evacuated volume; developing a vacuum state during operation expeditiously.