A deadbreak-to-loadbreak adapter assembly may include a deadbreak-to-loadbreak bushing having a first end and a second end, and an annular shoulder portion located between the first end and the second end. The output waveform correcting unit corrects the waveform of the output signal of the magnetic sensor based on the voltage level of the output signal of the magnetic sensor, in such a way that the output signal of the magnetic sensor is shaped to prescribed waveform shape during operation of the electric motor. A downhole receiver in hydraulic communication with the non-venting pulser is adapted to detect the pressure fluctuations in the drilling fluid. The lock in this position is in a locking position, and the retention of the post in the slot of the lock retains the ground engaging tool to the adapter. Medicinal products containing the same which are useful as bradycardics. Methods of the invention include administering, an effective amount of GDF-1 alone or in combination with neurotrophin-3, to a patient in need of such treatment such as a person suffering from stroke or traumatic brain injury or a neurodegenerative disease.