The invention concerns a method for detecting changes in a first flow of a heating or cooling medium in a refrigeration system whereby the first flow is conveyed through a heat exchanger wherein occurs heat transfer from the first flow to a second flow of a heating or cooling medium. In unstimulated saliva, the ration of Apo A to Apo B is correlated with the ration of HDL to LDL in serum. At least one wire is also coupled to the cell that is routed adjacent to the global interconnect for carrying the other output signal to provide active shielding for the global interconnect, thereby increasing signal integrity and signal transmission of the global interconnect. Upon a triggering condition, the plurality of latches simultaneously samples the signals from the plurality of signal lines.