The present invention relates to the discovery of a transdermal delivery system that can deliver high molecular weight pharmaceuticals and cosmetic agents to skin cells. The chair is constructed having an improved compressible, generally bell-shape support structure having two pairs of opposing arched-shaped openings in the middle section forming two intersecting arches, each arch having a pair of opposing flexible legs that bow outward when a pre-determined load is applied to the upper section. A design environment may be devised to facilitate designers in generating resource scripts, e. An hourglass-shaped absorbent pledget is disposed between the core and the coverstock. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases and as controls in assays for the identification of CCR2 antagonists. The tight-buffer coating has a limiting oxygen index of at least 20% and preferably has a durable tensile strength.