Embodiments described herein generally relate to flash memory devices and methods for manufacturing flash memory devices. An optical system including a lens assembly comprising a lens unit comprising at least one lens and a moveable lens frame supporting the lens unit; and an actuator assembly as disclosed above. The derivatives are chosen to have log P values below about 6. Furthermore, the first metal produces a first threshold voltage characteristic, wherein the first metal comprises tantalum. In certain preferred embodiments, the aromatase inhibitor is administered in conjunction with methotrexate. The tabular silver halide grains are dispersed in a hydrophilic polymeric vehicle mixture comprising at least 0.