Systems and methods are disclosed for detecting or diagnosing diseases by sampling and testing intra-oral fluids. The watch includes at least one processing and control circuit provided with a time base, hands to indicate a time, the hands being driven by a motorized device controlled by the processing and control circuit, and a device to store identification data. The actuator has at least one indicator window located thereon. This invention provides increased control and efficiency for the use of percussive force in horizontal directional drilling operations. Also disclosed are methods of using such compounds in the treatment of conditions or diseases such as prostate cancer, and methods of using such compounds in the inhibition of 17\u03b2-hydroxysteroid dehydrogenase type 3 enzyme.