The present invention relates to compounds that inhibit bacterial gyrase andor Topo IV and pharmaceutically acceptable compositions comprising said compounds. First, an image area and a scan area are specified on a surface of the sample. The shear wave transmission device is responsive to the acoustic radiation force source to transmit shear waves through the biologic material. After a read request is delivered to a memory device, the memory controller initiates a transmission flag to the memory device at a time equal to the system CAS latency, indicating that it is safe to transmit the requested data from the memory device to the memory controller.