A technique for maintaining network integrity is disclosed. Such compositions can be administered using devices, systems and methods for direct delivery of the compositions to the brain, or using devices, systems, methods of delivery, and compositions that deliver small interfering RNA or vectors containing the DNA encoding the small interfering RNA across the blood-brain barrier. A temperature control device is used to heat the wafer during an oxide reduction process or during burn-in of the wafer. The physical address is compared with the block addresses in the block correlation table.