The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. A mass spectrometry analyte support with nanotube anchors are used to concentrate MALDI samples, specifically samples prepared with water-insoluble matrix compounds, on the anchor spot. The bore has an inlet aperture and at least one exit aperture. The inlet port is in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber and provides fluid communication between a region exterior to the de-agglomerator and the swirl chamber. The first connector is engaged with a top end of the outer tube and is engaged with the second connector.