The present invention covers macrocyclic compounds of formula I active in-vitro and in cellular assays against the NS3 protease of the hepatitis C virus. An expansion chamber is defined within the expansion chamber. A CRD of the invention can be applied to the epicardium of the heart to locally constrain expansion of the cardiac wall or to circumferentially constrain the cardiac wall during cardiac expansion. The center cross member includes a first end connected to the first edge member and a second end connected to the second edge member. The body also has an integral handle for lifting the container and the container neck supports a bail-type handle also for lifting said container.