Substituted 3,4-dihydropyrido1,2-apyrimidines of formula Iand processes for the production thereof Also disclosed are substance libraries and pharmaceutical compositions containing the compound, and methods of treatment for pain, urinary incontinence, pruritus, tinnitus andor diarrhoea using the pharmaceutical composition. A package is created having a first die on a first side of a base substrate and a second die on a second side of the base substrate in opposed relation to the first die. The fluid filter apparatus can include a container defining an interior area wherein the filter device is positioned within the interior area.