To provide a construction machine capable of encouraging an operator to perform the driving and the operation for enhancing fuel efficiency. Pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and prevention of inflammatory, allergic, autoimmune, metabolic, cancer andor cardiovascular diseases, particularly diabetes, Crohn’s disease, atherosclerosis, and multiple sclerosis, along with methods of preparing compounds and intermediates therefor. Opposed ends of the bow shape are brought together to extend the extrusion barriers and compress the sealing element.