The present invention relates to antisense oligonucleotides that modulate the expression of andor function of a Reprogramming factor, in particular, by targeting natural antisense polynucleotides of a Reprogramming factor. Each device may have one or more operating frequencies and each operating frequency may generate a corresponding intensity modulation with respect to the signal. , it is possible to suppress deterioration of reception characteristic due to vanishing of correlation among bits transmitted at the same time.