A method of metal doping a chalcogenide material includes forming a metal over a substrate. The method includes depositing a magnetic write pole material over a substrate, and then forming a magnetic step structure over the magnetic write pole material. Each router exhibiting a difference is assessed to determine whether the difference may have been propagated to this router from another router. In addition, methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role are provided.