Pyrimidine deriviatives are ubiquination inhibitors that inhibit the ubiquitin ligase activity, particularly of POSH polypeptides, are useful for the treatment of viral infections and neurological disorders. Specifically, a control path is included within a network device that is independent of the data path and dedicates control path resources to each distributed processor within the network device. The controller couples with both the regulator and DC-to-DC converter, and the controller is configured to activate and deactivate the regulator and the DC-to-DC converter depending on an output demand. The inlet port may be configured to receive and direct a fluid into inlet manifold passages.