A CD or DVD disc processor, as shown, a recorder or duplicator has a pivoting picker mechanism having only one degree of freedom when driven for handling the discs for recording and stacking recorded discs. The generic format can be an e-mail message, such as a Simple Mail Transfer Protocol message. The compositions also have adhesive properties when cured with or without functional organic materials. An alcove structure mounting adaptor may be mounted in the opening, with the alcove structure being mounted to the adaptor. The bend adjustable mechanism has a plurality of spacer structures that individually adjust a distance between the first bearing structure and the second bearing structure in a radial direction of the roller. The methods according to the invention enable both decreasing the immunostimulatory effect for antisense applications, as well as increasing the immunostimulatory effect for immunotherapy applications.