The use of bissulfonamides for producing medicines for the treatment of hyperlipidemia. The coupling means comprises, on the same side as the first chamber, a first shut-off member, and, on the same side as the second chamber, a second shut-off member comprising a second flange forming a seat for a second removable shutter element. The glossiness of the fine irregularities 5 formed by such a random pattern is equal or less than 35%. A first conductive line and a second conductive line are over the insulation region. The method further includes a linear movement of the receptacle and a simultaneous pivoting movement of the needle, during which movements the free end of said needle is moved between a terminal position outside said receptacle and a terminal position inside it.