In an embodiment, a method to automatically select groups of signals to be multiplexed on pins of a programmable logic device in a programmable logic device implementation of at least a portion of an integrated circuit is contemplated. Also provided are methods of using such agonists to treat metabolic diseases alone or in combination with other active agents. When the second end of the shaft is grasped and a rotational force imparted to the shaft, the crank handle is caused to rotate.