A process for preparing mannitol from fructose is described and entails the hydrogenation of fructose taking place in the presence of a Raney copper catalyst and being carried out continuously. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer. Such devices can be configured to reflect enough light of select wavelengths so as to impart a color, while transmitting enough light to the PV active material so as to generate useful electricity. The devices include such conduits and valves for forming the fluid communication pathways.