The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. An electrical measuring device detects a change in an electrical parameter between two of the terminals when ink is in the gap between the at least two terminals. The backup belt may be wrapped about the housing structure including the nip forming pressure roll. The insulated states of these groups are discriminated, and the insulated states of the respective contacts in the respective groups are discriminated if the insulated states of the respective groups are judged to be satisfactory. A method in accordance with an embodiment of the present invention includes: providing RAS assets for each different lifecycle phase of a software asset; and linking the RAS assets together using RAS related-assets. The aim of the invention is to improve the construction and functioning of the valve control.