The invention relates to overcoming anti-cancer therapy resistance in melanoma by regulation of the expression of tyrosinase related protein 2. The ion source further includes a repeller having a repeller surface positioned opposite the emitter surface, and a hollow cathode coupled to the repeller and configured to provide a feed material into the arc chamber. The lower levels of additives andor crosslinking produce crosslinked UHMWPE having desired physical properties not possible without the synergistic interaction of the additives. The router forwards the request to the web server. The second section is initially filled with fresh water. Each rocker includes a discharge valve movable in translation with respect to the rocker, adapted to reduce fluid pressure in the chamber.