An image registration system for aligning first and second images. The single-crystal metal structure has a crystallographic orientation, a length, a first side, a second side, and a first axis extending through the structure. The diagnostic formulation optionally comprises a radiolabeled dopamine transporter ligand useful in the diagnosis of Parkinson’s disease. In a light detector or imaging application, the SiC composition is selected to provide sensitivity to the desired wavelength of light.