Device for increasing the training effect in a horse, consisting of essentially a sheet of mat-like material adapting to and attachable to the horse’s back. The method involves administering to the patient a urokinase plasminogen activator inhibiting effective amount of a compound of the formula :. A transparent wafer is then applied so that the fluid structure is covered. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils. The first duct includes an annular channel that is placed, preferably concentrically, between the second duct and the annular channel of the third duct. Neo acid esters are made by contacting a neo acid stream, comprising a mixture of neo acids, with alcohol in the presence of a catalyst.