The present invention 1 includes compounds of formula ,and their pharmaceutically acceptable salts. A passageway extends between the first end and the second end of the male coupling component for conveying the pressure. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. \u201d A system and method may also send an alarm signal during such an attack by using predictive analysis of real-time events. The invention leverages the use of existing wiring and is particularly useful in heating and air conditioning systems, sprinkler control systems, security systems, lighting control systems, industrial automation control systems and similar environments. This invention also discloses a scheme to tolerate jitters from the clock source.