An ESD protection circuit includes a silicon controlled rectifier coupled between a circuit pad and ground for bypassing an ESD current from the circuit pad during an ESD event. The substrate includes a hole extending through the substrate. The opening can be closed with a cover. As the compounds reactive with aldehydes, organic amines, organic amine salts, compounds producing organic amines by the reaction with discharges, organic amines, amide compounds, and compounds having a mercapto group can be used. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine.