Methods and systems for improving the reliability of C4 solder ball contacts performed at the design stage to reduce the incidence of thermally-induced failures, including those due to electromigration and thermal cycling. A pixel structure is determined so that even if a gap or a an overlapping portion is generated in a boundary between a plurality of semiconductor substrates, a single-crystal semiconductor layer does not overlap with the gap or the overlapping portion. Initiating comments and replies may be posted to a discussion topic for review by participants. Each of the longitudinal and lateral folds extends into an associated one of the pleats. A shank portion on each member is tuned to provide an appropriate spring force to hold the seal surfaces together. The invention also encompasses a class of the compounds with the novel property of anti-tumor activity against human breast cancer, which includes the following compounds 4–2–2-hydroxy-4-oxo-butyric acid methyl ester ; 2-N-1–ethylidene-hydrazino-4-oxo-4-phenyl-but-2-enoic acid methyl ester ; 2–4-oxo-4-phenyl-but-2-enoic acid methyl ester ; and 4-Chloro-4–2–but-3-enoic acid methyl ester.