The present invention includes an optical amplifier and method for reducing the impact of transient events within an optical transmission system. and across different disciplines and jurisdictions. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. A distribution schedule can indicate one or more distribution systems to which to distribute the software package.