An indexable cutting insert has at least first and second cutting edges and first and second edge-location surfaces associated with the first and second cutting edges, respectively. The present invention also relates to a pharmaceutical composition comprising a compound such as N-methyl-2-3–2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl-benzamide, that inhibits the T315I mutation in BCR-ABL tyrosine kinase, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Octahydro-pyrrolo3,4-bpyrrole N-oxide compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein. An optical signal generator sends signals to the workstation to imitate a standard transmit and receive connection, and also sends signals to the second media converter to imitate a standard transmit and receive connection. The flange is mounted against the structure through a mounting hole. A snowmobile frame and a snowmobile having the footrest are also disclosed.