An exemplary embodiment of the present invention is directed toward a method and system for cancelling line echo in the presence of a known secondary audio signal. A primary flow control system is used to provide a first barrier to formation fluids in the inner bore and annulus of the drill string. A primary clock circuit provides the timing for the processing circuit. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. The epoxy resins are preferably a Bisphenol A or Bisphenol F Epichlorohydrin based epoxy or epoxy novalac. At that time, information indicating the maximum reference index value is coded and included into the coded image signal, and the commands indicating correspondence between at least one picture number and a plurality of reference indices are generated.