An optical core node that includes optical switching planes interfaces, at input, with multi-channel input links and, at output, with multi-channel output links. A method for the treatment of stenosis in a patient comprising performing an intervention for the treatment of stenosis in conjunction with administering a therapeutically effective amount of Annexin A5 or a functional analog or variant thereof. The radiation system also includes a plasma recombination surface that is arranged proximate to the pinch, and is configured to neutralize a plurality of plasma particles. Thus, a plurality of well regions of individual conductive types where substrate-bias variable transistors of individual conductive types are provided can be made electrically independent of one another, allowing the power consumption to be reduced.