A database system and method for adjusting a value within a database configured as a multidimensional aggregation tree having a plurality of leaves. The disk drive includes a magnetic media for storing information using an actuator arrangement to perform a data access by moving at least one head proximate to the magnetic media. The method further includes selecting a harmonic to provide to an input of a mixer to generate an output signal. After an actuation of the first button, the return spring causes the flange of the second button to force the first button back to an idle position. The pin includes an abutment movable to a locked configuration in the second portion of the opening, wherein the abutment defines a cross-sectional dimension greater than that of the first portion of the opening. The method provided includes assessing the ability of the compound to form a complex with the lipoprotein, and then determining whether the newly formed complex causes a change in the structure of apoB-100 that results in increased binding affinity to an LDL receptor.