The present invention are macrocycles of the formula :for treating Alzheimer’s disease and other similar diseases. The ith memory cell comprises a second stacked layer structure in which a first insulating layer, a charge storage layer, a second insulating layer, and a control gate electrode are stacked. In the vicinity of the magnetic circuit, a sub coil portion of the focusing coils and a magnetic flux-controlling member are provided for interlinking with a leakage magnetic flux generated from the magnetic circuit and for controlling quantity of the so generated and interlinking leakage magnetic flux, respectively. A first valve in a first opening is disposed to communicate with the first part of the combustion chamber, and a second valve in a second opening is disposed to communicate with the second part of the combustion chamber.