An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The at least one clamping unit is configured to fixedly clamp a machining tool in an axial direction. A cutting element extends within the lumen through the proximal segment of the lumen and extends exterior of the elongate shaft along the distal segment of the lumen. The static eliminator contacts with the surface and discharges the surface to a second voltage. The photodiode region receives light from the back surface of the semiconductor substrate. This is particularly applicable to the treating of neuropathic pain in patients suffering from spinal cord injuries.