Provided are methods and compositions for increasing CD4+ cell count in mammals, preferably by at least 25%, while undergoing treatment for various conditions whose treatment can have detrimental effects on immune system function. Light-emitting diodes are preferably used as the light source. The retention element is further configured to retain the pillow insert relative to the bed by tucking the retention element under the mattress of the bed. The imaging means is arranged in a predetermined position for the GPS positional positioning means.