A malfunction detecting device for an internal combustion engine is mounted on a vehicle and includes an engine and a control unit. Also described is a method of judging various pathological conditions such as the pathological conditions of diabetes, the risks of coronary artery diseases, and the pathological conditions of myocardial infarction using levels of vitamin E components in the lipoprotein as an index. A plug is fitted into the pressurized gas chamber end of the cartridge and a valve to the product chamber end, the valve has a valve house, a valve stem, and a disc spring with plate segments. The fifth lens is formed with at least one of its convex surfaces being an aspherical surface.