In a skin needle manufacturing apparatus 10, a material melted in a syringe 45 is discharged from a fine hole 47a of a pin member 47 and is caused to adhere to a base 48. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. The axle-positioning members slidably engage channels of a structural support member. An incoming light beam may be homogenized and may be split into at least two outgoing beams that may be diverted at right angles at reflection sections.